{"id":38810,"date":"2025-10-23T15:12:16","date_gmt":"2025-10-23T18:12:16","guid":{"rendered":"https:\/\/www.grupomedcof.com.br\/blog\/?p=38810"},"modified":"2025-10-23T15:12:19","modified_gmt":"2025-10-23T18:12:19","slug":"discrasias-plasmocitarias","status":"publish","type":"post","link":"https:\/\/www.grupomedcof.com.br\/blog\/discrasias-plasmocitarias\/","title":{"rendered":"Discrasias Plasmocit\u00e1rias: o que s\u00e3o, abordagem e diagn\u00f3stico"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_74 counter-hierarchy ez-toc-counter ez-toc-transparent ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Sum\u00e1rio<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Alternar tabela de conte\u00fado\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/discrasias-plasmocitarias\/#O_que_sao_as_discrasias_plasmocitarias\" >O que s\u00e3o as discrasias plasmocit\u00e1rias?\u00a0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/discrasias-plasmocitarias\/#Gamopatia_Monoclonal_de_Significado_Incerto_MGUS\" >Gamopatia Monoclonal de Significado Incerto (MGUS)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/discrasias-plasmocitarias\/#Mieloma_Multiplo_MM\" >Mieloma M\u00faltiplo (MM)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/discrasias-plasmocitarias\/#Amiloidose_Primaria_Sistemica_AL\" >Amiloidose Prim\u00e1ria Sist\u00eamica (AL)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/discrasias-plasmocitarias\/#Sindrome_POEMS\" >S\u00edndrome POEMS<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/discrasias-plasmocitarias\/#Macroglobulinemia_de_Waldenstrom_MW\" >Macroglobulinemia de Waldenstr\u00f6m (MW)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/discrasias-plasmocitarias\/#Conquiste_a_aprovacao_e_acompanhe_mais_conteudos\" >Conquiste a aprova\u00e7\u00e3o e acompanhe mais conte\u00fados!<\/a><\/li><\/ul><\/nav><\/div>\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/Blog-MedCof-2025-10-23T151104.014-1024x576.jpg\" alt=\"\" class=\"wp-image-38817\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/Blog-MedCof-2025-10-23T151104.014-1024x576.jpg 1024w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/Blog-MedCof-2025-10-23T151104.014-300x169.jpg 300w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/Blog-MedCof-2025-10-23T151104.014-768x432.jpg 768w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/Blog-MedCof-2025-10-23T151104.014-1536x864.jpg 1536w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/Blog-MedCof-2025-10-23T151104.014-747x420.jpg 747w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/Blog-MedCof-2025-10-23T151104.014-150x84.jpg 150w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/Blog-MedCof-2025-10-23T151104.014-696x392.jpg 696w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/Blog-MedCof-2025-10-23T151104.014-1068x601.jpg 1068w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/Blog-MedCof-2025-10-23T151104.014.jpg 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>As <strong>discrasias plasmocit\u00e1rias<\/strong> s\u00e3o um grupo de dist\u00farbios caracterizados pela <strong>prolifera\u00e7\u00e3o clonal de plasm\u00f3citos. <\/strong>Essa prolifera\u00e7\u00e3o leva \u00e0 produ\u00e7\u00e3o de <strong>Prote\u00edna M<\/strong>. O espectro dessas doen\u00e7as inclui condi\u00e7\u00f5es como a <strong>Gamopatia Monoclonal de Significado Incerto (MGUS), o Mieloma M\u00faltiplo, a Amiloidose AL e a Macroglobulinemia de Waldenstr\u00f6m.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-o-que-sao-as-discrasias-plasmocitarias\"><span class=\"ez-toc-section\" id=\"O_que_sao_as_discrasias_plasmocitarias\"><\/span><strong>O que s\u00e3o as discrasias plasmocit\u00e1rias?\u00a0<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>As discrasias plasmocit\u00e1rias compreendem um grupo de dist\u00farbios caracterizados pela <strong>prolifera\u00e7\u00e3o clonal de plasm\u00f3citos, <\/strong>que s\u00e3o<strong> c\u00e9lulas B ultra especializadas<\/strong>. Essa prolifera\u00e7\u00e3o resulta na produ\u00e7\u00e3o de uma prote\u00edna monoclonal <strong>(Prote\u00edna M<\/strong>), que \u00e9 imunologicamente homog\u00eanea e disfuncional.<\/p>\n\n\n\n<p>O m\u00e9todo de triagem para essas condi\u00e7\u00f5es \u00e9 a <strong>eletroforese de prote\u00ednas s\u00e9ricas<\/strong>. Nela, a Prote\u00edna M se apresenta como um<strong> pico de base estreita na regi\u00e3o das gamaglobulinas<\/strong> (pico monoclonal), diferentemente do aumento policlonal (visto em infec\u00e7\u00f5es, hepatopatias ou doen\u00e7as autoimunes), que se manifesta como uma <strong>banda de base ampla.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"941\" height=\"525\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-39.png\" alt=\"\" class=\"wp-image-38811\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-39.png 941w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-39-300x167.png 300w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-39-768x428.png 768w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-39-753x420.png 753w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-39-150x84.png 150w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-39-696x388.png 696w\" sizes=\"auto, (max-width: 941px) 100vw, 941px\" \/><figcaption class=\"wp-element-caption\">Eletroforese das prote\u00ednas s\u00e9ricas.Fonte: Acervo de aulas do grupo MedCof.\u00a0<\/figcaption><\/figure>\n\n\n\n<p>Abaixo, detalhamos as principais entidades dentro desse espectro.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-gamopatia-monoclonal-de-significado-incerto-mgus\"><span class=\"ez-toc-section\" id=\"Gamopatia_Monoclonal_de_Significado_Incerto_MGUS\"><\/span><strong>Gamopatia Monoclonal de Significado Incerto (MGUS)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>A MGUS \u00e9 a discrasia plasmocit\u00e1ria pr\u00e9-maligna<strong> mais comum<\/strong>, n\u00e3o sendo considerada um c\u00e2ncer. \u00c9 uma condi\u00e7\u00e3o precursora que pode evoluir para<strong> Mieloma M\u00faltiplo, Amiloidose AL ou Macroglobulinemia de Waldenstr\u00f6m.<\/strong> Sua preval\u00eancia aumenta significativamente com a idade.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Diagn\u00f3stico:<\/strong> \u00c9 definido pela combina\u00e7\u00e3o de<strong> tr\u00eas crit\u00e9rios:<\/strong>\n<ol class=\"wp-block-list\">\n<li>Pico monoclonal &lt; 3 g\/dL.<\/li>\n\n\n\n<li>Infiltra\u00e7\u00e3o de plasm\u00f3citos clonais na medula \u00f3ssea &lt; 10%.<\/li>\n\n\n\n<li>Aus\u00eancia de les\u00f5es de \u00f3rg\u00e3o-alvo (crit\u00e9rios CRAB).<\/li>\n<\/ol>\n<\/li>\n\n\n\n<li><strong>Quadro Cl\u00ednico:<\/strong> A MGUS \u00e9, por defini\u00e7\u00e3o, assintom\u00e1tica.<\/li>\n\n\n\n<li><strong>Manejo:<\/strong> Apresenta baixo risco de evolu\u00e7\u00e3o, mas exige acompanhamento regular com hematologista.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-mieloma-multiplo-mm\"><span class=\"ez-toc-section\" id=\"Mieloma_Multiplo_MM\"><\/span><strong>Mieloma M\u00faltiplo (MM)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>O Mieloma M\u00faltiplo \u00e9 uma neoplasia hematol\u00f3gica caracterizada pela prolifera\u00e7\u00e3o clonal de plasm\u00f3citos an\u00f4malos. O subtipo mais comum \u00e9 o produtor de IgG. \u00c9 uma doen\u00e7a mais frequente em idosos, com idade m\u00e9dia ao diagn\u00f3stico entre 65 e 70 anos.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Fisiopatologia e Cl\u00ednica:<\/strong> A doen\u00e7a \u00e9 definida pela presen\u00e7a de les\u00e3o de \u00f3rg\u00e3o-alvo, resumida pelo acr\u00f4nimo <strong>CRAB<\/strong>:\n<ul class=\"wp-block-list\">\n<li><strong>C:<\/strong> Hiper<strong>c<\/strong>alcemia (C\u00e1lcio > 11 mg\/dL).<\/li>\n\n\n\n<li><strong>R:<\/strong> Insufici\u00eancia <strong>R<\/strong>enal (Creatinina > 2 mg\/dL ou ClCr &lt; 40 ml\/min).<\/li>\n\n\n\n<li><strong>A:<\/strong> <strong>A<\/strong>nemia (Hb &lt; 10 g\/dL).<\/li>\n\n\n\n<li><strong>B:<\/strong> Les\u00f5es \u00f3sseas (&#8220;<strong>B<\/strong>one&#8221;), que s\u00e3o tipicamente les\u00f5es l\u00edticas.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"725\" height=\"502\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-40.png\" alt=\"\" class=\"wp-image-38812\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-40.png 725w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-40-300x208.png 300w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-40-607x420.png 607w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-40-150x104.png 150w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-40-218x150.png 218w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-40-696x482.png 696w\" sizes=\"auto, (max-width: 725px) 100vw, 725px\" \/><figcaption class=\"wp-element-caption\">Representa\u00e7\u00e3o dos crit\u00e9rios CRAB. Fonte: Acervo de Ilustra\u00e7\u00f5es do Grupo MedCof.\u00a0<\/figcaption><\/figure>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Achados Adicionais:<\/strong> A principal causa de \u00f3bito \u00e9 a <strong>infec\u00e7\u00e3o<\/strong>, devido \u00e0 produ\u00e7\u00e3o de imunoglobulinas disfuncionais. No sangue perif\u00e9rico, \u00e9 comum o achado de hem\u00e1cias em <strong><em>Rouleaux<\/em><\/strong><strong> <\/strong>(empilhamento), causado pela perda do potencial <strong>ZETA<\/strong> da membrana pela deposi\u00e7\u00e3o de imunoglobulinas.<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"674\" height=\"504\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-42.png\" alt=\"\" class=\"wp-image-38814\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-42.png 674w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-42-300x224.png 300w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-42-562x420.png 562w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-42-80x60.png 80w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-42-150x112.png 150w\" sizes=\"auto, (max-width: 674px) 100vw, 674px\" \/><figcaption class=\"wp-element-caption\">Representa\u00e7\u00e3o do Efeito ZETA. Fonte: Acervo de aulas do Grupo MedCof.<\/figcaption><\/figure>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Diagn\u00f3stico:<\/strong> Requer a presen\u00e7a de <strong>>10% de plasm\u00f3citos <\/strong>na medula \u00f3ssea (ou um plasmocitoma) <em>associado<\/em> a <strong>um ou mais dos crit\u00e9rios CRAB<\/strong>. O diagn\u00f3stico tamb\u00e9m pode ser fechado na aus\u00eancia de CRAB se houver <strong>marcadores de alta carga tumoral<\/strong> (ex: >60% de plasm\u00f3citos na medula).<\/li>\n\n\n\n<li><strong>Estadiamento:<\/strong> Utiliza o sistema<strong> R-ISS<\/strong>, que classifica o risco com base nos n\u00edveis de B2-microglobulina, albumina, LDH e a presen\u00e7a de<strong> altera\u00e7\u00f5es gen\u00e9ticas<\/strong> de alto risco por FISH.<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"419\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-41-1024x419.png\" alt=\"\" class=\"wp-image-38813\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-41-1024x419.png 1024w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-41-300x123.png 300w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-41-768x314.png 768w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-41-1027x420.png 1027w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-41-150x61.png 150w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-41-696x285.png 696w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-41.png 1032w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Diagrama de condu\u00e7\u00e3o conforme R-ISS. Fonte: Acervo de aulas do Grupo MedCof.\u00a0<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-amiloidose-primaria-sistemica-al\"><span class=\"ez-toc-section\" id=\"Amiloidose_Primaria_Sistemica_AL\"><\/span><strong>Amiloidose Prim\u00e1ria Sist\u00eamica (AL)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>A Amiloidose AL \u00e9 uma discrasia plasmocit\u00e1ria onde o dano tecidual \u00e9 causado pelo dep\u00f3sito sist\u00eamico de fibrilas amiloides compostas por cadeias leves monoclonais. A cadeia leve <strong>lambda<\/strong> \u00e9 a mais comumente envolvida.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Quadro Cl\u00ednico:<\/strong> \u00c9 uma doen\u00e7a de envolvimento sist\u00eamico, r\u00e1pido e agressivo. As manifesta\u00e7\u00f5es dependem do \u00f3rg\u00e3o-alvo:\n<ul class=\"wp-block-list\">\n<li><strong>Rins:<\/strong> Protein\u00faria nefr\u00f3tica (n\u00e3o diab\u00e9tica) e insufici\u00eancia renal.<\/li>\n\n\n\n<li><strong>Cora\u00e7\u00e3o:<\/strong> Miocardiopatia restritiva (respons\u00e1vel por 50% dos \u00f3bitos) e baixa voltagem no ECG.<\/li>\n\n\n\n<li><strong>Sinais Cl\u00e1ssicos:<\/strong> <strong>Macroglossia<\/strong> (aumento da l\u00edngua) e <strong>P\u00farpura Periorbital<\/strong> (equimose ao redor dos olhos, &#8220;olhos de guaxinim&#8221;).<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"470\" height=\"406\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-43.png\" alt=\"\" class=\"wp-image-38815\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-43.png 470w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-43-300x259.png 300w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-43-150x130.png 150w\" sizes=\"auto, (max-width: 470px) 100vw, 470px\" \/><figcaption class=\"wp-element-caption\">Caso de macroglossia. Fonte: Acervo de aulas do Grupo MedCof.\u00a0<\/figcaption><\/figure>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Outros:<\/strong> Hepatoesplenomegalia, pneumopatia, polineuropatia e s\u00edndrome do t\u00fanel do carpo.<\/li>\n\n\n\n<li><strong>Diagn\u00f3stico:<\/strong> O diagn\u00f3stico requer bi\u00f3psia tecidual, sendo a <strong>gordura abdominal<\/strong> o s\u00edtio de elei\u00e7\u00e3o. A confirma\u00e7\u00e3o \u00e9 feita pela colora\u00e7\u00e3o <strong>Vermelho do Congo<\/strong> positiva no tecido.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-sindrome-poems\"><span class=\"ez-toc-section\" id=\"Sindrome_POEMS\"><\/span><strong>S\u00edndrome POEMS<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>A POEMS \u00e9 uma desordem plasmocit\u00e1ria rara, mais frequente ap\u00f3s os 50 anos, cuja fisiopatologia envolve a superprodu\u00e7\u00e3o de citocinas pr\u00f3-inflamat\u00f3rias, em especial o <strong>VEGF<\/strong>.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Quadro Cl\u00ednico:<\/strong> O nome \u00e9 um acr\u00f4nimo para suas principais manifesta\u00e7\u00f5es:\n<ul class=\"wp-block-list\">\n<li><strong>P<\/strong>olineuropatia.<\/li>\n\n\n\n<li><strong>O<\/strong>rganomegalia.<\/li>\n\n\n\n<li><strong>E<\/strong>ndocrinopatia.<\/li>\n\n\n\n<li>Prote\u00edna <strong>M<\/strong>onoclonal.<\/li>\n\n\n\n<li>Altera\u00e7\u00f5es de Pele (&#8220;<strong>S<\/strong>kin changes&#8221;).<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Diferencial:<\/strong> Diferente do Mieloma M\u00faltiplo, as les\u00f5es \u00f3sseas na POEMS s\u00e3o tipicamente <strong>osteoescler\u00f3ticas<\/strong> (e n\u00e3o l\u00edticas).<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-macroglobulinemia-de-waldenstrom-mw\"><span class=\"ez-toc-section\" id=\"Macroglobulinemia_de_Waldenstrom_MW\"><\/span><strong>Macroglobulinemia de Waldenstr\u00f6m (MW)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>A MW \u00e9 uma desordem linfoproliferativa (e n\u00e3o puramente plasmocit\u00e1ria) caracterizada pelo ac\u00famulo da imunoglobulina monoclonal <strong>IgM<\/strong>.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Fisiopatologia:<\/strong> A IgM \u00e9 um pent\u00e2mero (uma mol\u00e9cula grande), e seu excesso leva \u00e0 complica\u00e7\u00e3o mais temida: a <strong>S\u00edndrome de Hiperviscosidade<\/strong>.<\/li>\n\n\n\n<li><strong>Quadro Cl\u00ednico:<\/strong> A hiperviscosidade \u00e9 uma emerg\u00eancia m\u00e9dica. Causa altera\u00e7\u00f5es visuais, cefaleia, vertigem, nistagmo, ataxia e pode levar \u00e0 descompensa\u00e7\u00e3o de insufici\u00eancia card\u00edaca.<\/li>\n\n\n\n<li><strong>Tratamento (da Hiperviscosidade):<\/strong> A medida de emerg\u00eancia \u00e9 a <strong>Plasmaf\u00e9rese<\/strong> para remover o excesso de IgM. Deve-se evitar transfus\u00f5es sangu\u00edneas, pois elas podem aumentar ainda mais a viscosidade. O tratamento definitivo visa a doen\u00e7a de base.<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"504\" height=\"563\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-44.png\" alt=\"\" class=\"wp-image-38816\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-44.png 504w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-44-269x300.png 269w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-44-376x420.png 376w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-44-150x168.png 150w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/10\/image-44-300x335.png 300w\" sizes=\"auto, (max-width: 504px) 100vw, 504px\" \/><figcaption class=\"wp-element-caption\">Fonte: Acervo de aulas do Grupo MedCof.\u00a0<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-conquiste-a-aprovacao-e-acompanhe-mais-conteudos\"><span class=\"ez-toc-section\" id=\"Conquiste_a_aprovacao_e_acompanhe_mais_conteudos\"><\/span><strong>Conquiste a aprova\u00e7\u00e3o e acompanhe mais conte\u00fados!<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Gostou da novidade? Continue acompanhando nosso blog para ficar por dentro das principais\u00a0<strong>not\u00edcias sobre resid\u00eancia m\u00e9dica, editais e oportunidades que podem transformar sua carreira!<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"youtube-embed\" data-video_id=\"NfVL9CWLnIE\"><iframe loading=\"lazy\" title=\"Entendendo as Discrasias Plasmocit\u00e1rias: Sintomas e Tratamentos. Com Dra. Carolina Perrone\" width=\"696\" height=\"392\" src=\"https:\/\/www.youtube.com\/embed\/NfVL9CWLnIE?feature=oembed&#038;enablejsapi=1\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>As discrasias plasmocit\u00e1rias s\u00e3o um grupo de dist\u00farbios caracterizados pela prolifera\u00e7\u00e3o clonal de plasm\u00f3citos. Clique e entenda mais sobre!<\/p>\n","protected":false},"author":21,"featured_media":38817,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2600],"tags":[3275,3277,3276,3279,3278],"ppma_author":[3617],"class_list":{"0":"post-38810","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-hematologia","8":"tag-crab","9":"tag-mgus","10":"tag-mieloma-multiplo","11":"tag-mw","12":"tag-poems"},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.3 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Discrasias Plasmocit\u00e1rias: o que s\u00e3o, abordagem e diagn\u00f3stico - Blog de Medcof: conte\u00fados, editais, revalida e mais!<\/title>\n<meta name=\"description\" content=\"As discrasias plasmocit\u00e1rias s\u00e3o um grupo de dist\u00farbios caracterizados pela prolifera\u00e7\u00e3o clonal de plasm\u00f3citos. 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