{"id":39740,"date":"2025-11-26T14:19:36","date_gmt":"2025-11-26T17:19:36","guid":{"rendered":"https:\/\/www.grupomedcof.com.br\/blog\/?p=39740"},"modified":"2025-11-25T15:18:26","modified_gmt":"2025-11-25T18:18:26","slug":"hipotese-monoaminergica","status":"publish","type":"post","link":"https:\/\/www.grupomedcof.com.br\/blog\/hipotese-monoaminergica\/","title":{"rendered":"Al\u00e9m da Hip\u00f3tese Monoamin\u00e9rgica: uma revis\u00e3o estrat\u00e9gica dos antidepressivos"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_74 counter-hierarchy ez-toc-counter ez-toc-transparent ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Sum\u00e1rio<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Alternar tabela de conte\u00fado\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/hipotese-monoaminergica\/#Quais_pacientes_precisam_de_antidepressivos\" >Quais pacientes precisam de antidepressivos?\u00a0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/hipotese-monoaminergica\/#Principais_Classes_de_Antidepressivos_e_Mecanismos_de_Acao\" >Principais Classes de Antidepressivos e Mecanismos de A\u00e7\u00e3o<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/hipotese-monoaminergica\/#1_ISRS_Inibidores_Seletivos_da_Recaptacao_de_Serotonina\" >1. ISRS (Inibidores Seletivos da Recapta\u00e7\u00e3o de Serotonina)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/hipotese-monoaminergica\/#2_IRSN_Inibidores_de_Recaptacao_de_Serotonina_e_Noradrenalina_%E2%80%93_Duais\" >2. IRSN (Inibidores de Recapta\u00e7\u00e3o de Serotonina e Noradrenalina &#8211; Duais)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/hipotese-monoaminergica\/#3_IRND_Inibidores_de_Recaptacao_de_Noradrenalina_e_Dopamina\" >3. IRND (Inibidores de Recapta\u00e7\u00e3o de Noradrenalina e Dopamina)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/hipotese-monoaminergica\/#4_Antidepressivos_Atipicos_e_Novos\" >4. Antidepressivos At\u00edpicos e Novos<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/hipotese-monoaminergica\/#5_ADT_Antidepressivos_Triciclicos\" >5. ADT (Antidepressivos Tric\u00edclicos)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/hipotese-monoaminergica\/#6_IMAO_Inibidores_da_Monoaminoxidase\" >6. IMAO (Inibidores da Monoaminoxidase)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/hipotese-monoaminergica\/#Complicacoes_e_Topicos_Especiais\" >Complica\u00e7\u00f5es e T\u00f3picos Especiais<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/hipotese-monoaminergica\/#Depressao_Resistente_ao_Tratamento\" >Depress\u00e3o Resistente ao Tratamento<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/hipotese-monoaminergica\/#Sindrome_Serotoninergica\" >S\u00edndrome Serotonin\u00e9rgica<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/hipotese-monoaminergica\/#Garanta_sua_vaga_na_residencia_medica_com_as_melhores_condicoes_do_ano\" >Garanta sua vaga na resid\u00eancia m\u00e9dica com as melhores condi\u00e7\u00f5es do ano!<\/a><\/li><\/ul><\/nav><\/div>\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/Blog-MedCof-2025-11-25T150854.271-1024x576.jpg\" alt=\"\" class=\"wp-image-39750\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/Blog-MedCof-2025-11-25T150854.271-1024x576.jpg 1024w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/Blog-MedCof-2025-11-25T150854.271-300x169.jpg 300w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/Blog-MedCof-2025-11-25T150854.271-768x432.jpg 768w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/Blog-MedCof-2025-11-25T150854.271-1536x864.jpg 1536w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/Blog-MedCof-2025-11-25T150854.271-747x420.jpg 747w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/Blog-MedCof-2025-11-25T150854.271-150x84.jpg 150w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/Blog-MedCof-2025-11-25T150854.271-696x392.jpg 696w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/Blog-MedCof-2025-11-25T150854.271-1068x601.jpg 1068w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/Blog-MedCof-2025-11-25T150854.271.jpg 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>A sele\u00e7\u00e3o de antidepressivos \u00e9 uma decis\u00e3o cl\u00ednica complexa, guiada pela estrutura qu\u00edmica e, principalmente, pelo<strong> mecanismo de a\u00e7\u00e3o de cada f\u00e1rmaco.<\/strong> Embora diversos agentes apresentem efic\u00e1cia semelhante para a maioria dos pacientes, a escolha terap\u00eautica \u00e9 refinada com base nos perfis de efeitos adversos e intera\u00e7\u00f5es medicamentosas.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-quais-pacientes-precisam-de-antidepressivos\"><span class=\"ez-toc-section\" id=\"Quais_pacientes_precisam_de_antidepressivos\"><\/span><strong>Quais pacientes precisam de antidepressivos?\u00a0<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>A terap\u00eautica baseia-se na hip\u00f3tese <strong>monoamin\u00e9rgica<\/strong>, que postula uma disfun\u00e7\u00e3o na neurotransmiss\u00e3o em estados depressivos. Clinicamente, os sintomas podem ser agrupados para orientar a escolha do f\u00e1rmaco:<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"340\" height=\"246\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-43.png\" alt=\"\" class=\"wp-image-39741\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-43.png 340w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-43-300x217.png 300w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-43-150x109.png 150w\" sizes=\"auto, (max-width: 340px) 100vw, 340px\" \/><figcaption class=\"wp-element-caption\">C\u00e9rebro normal. Fonte: Acervo de aulas do Grupo MedCof.\u00a0<\/figcaption><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"333\" height=\"249\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-44.png\" alt=\"\" class=\"wp-image-39742\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-44.png 333w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-44-300x224.png 300w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-44-80x60.png 80w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-44-150x112.png 150w\" sizes=\"auto, (max-width: 333px) 100vw, 333px\" \/><figcaption class=\"wp-element-caption\">C\u00e9rebro com depress\u00e3o. Fonte: Acervo de aulas do Grupo MedCof.\u00a0<\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Redu\u00e7\u00e3o do Afeto Positivo:<\/strong> Manifesta-se como humor deprimido, perda de interesse\/prazer, perda de energia e diminui\u00e7\u00e3o da autoconfian\u00e7a. Esta dimens\u00e3o est\u00e1 associada \u00e0 disfun\u00e7\u00e3o das vias de dopamina (DA) e\/ou noradrenalina (NA).<\/li>\n\n\n\n<li><strong>Aumento do Afeto Negativo:<\/strong> Inclui sintomas como culpa, avers\u00e3o, medo, ansiedade, hostilidade e irritabilidade. Esta dimens\u00e3o est\u00e1 ligada \u00e0 disfun\u00e7\u00e3o das vias de noradrenalina (NA) e\/ou serotonina (5HT).<\/li>\n<\/ol>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"710\" height=\"393\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-45.png\" alt=\"\" class=\"wp-image-39743\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-45.png 710w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-45-300x166.png 300w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-45-150x83.png 150w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-45-696x385.png 696w\" sizes=\"auto, (max-width: 710px) 100vw, 710px\" \/><figcaption class=\"wp-element-caption\">Sele\u00e7\u00e3o de tratamento baseado em sintomas: afetos positivo e negativo. Fonte: Acervo de aulas do Grupo MedCof.\u00a0<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-principais-classes-de-antidepressivos-e-mecanismos-de-acao\"><span class=\"ez-toc-section\" id=\"Principais_Classes_de_Antidepressivos_e_Mecanismos_de_Acao\"><\/span><strong>Principais Classes de Antidepressivos e Mecanismos de A\u00e7\u00e3o<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_ISRS_Inibidores_Seletivos_da_Recaptacao_de_Serotonina\"><\/span><strong>1. ISRS (Inibidores Seletivos da Recapta\u00e7\u00e3o de Serotonina)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Mecanismo de A\u00e7\u00e3o:<\/strong> Inibem seletivamente a recapta\u00e7\u00e3o de serotonina (SERT).<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"468\" height=\"536\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-46.png\" alt=\"\" class=\"wp-image-39744\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-46.png 468w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-46-262x300.png 262w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-46-367x420.png 367w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-46-150x172.png 150w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-46-300x344.png 300w\" sizes=\"auto, (max-width: 468px) 100vw, 468px\" \/><figcaption class=\"wp-element-caption\">Mecanismo farmacol\u00f3gico dos Inibidores Seletivos de Recapta\u00e7\u00e3o de Serotonina. Fonte: Acervo de aulas do Grupo MedCof.\u00a0<\/figcaption><\/figure>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>F\u00e1rmacos:<\/strong> Fluoxetina, Sertralina, Citalopram, Escitalopram, Paroxetina e Fluvoxamina.<\/li>\n\n\n\n<li><strong>Caracter\u00edsticas Gerais:<\/strong>\n<ul class=\"wp-block-list\">\n<li>Apresentam ampla janela terap\u00eautica e baixo perfil de efeitos colaterais.<\/li>\n\n\n\n<li>O in\u00edcio de a\u00e7\u00e3o terap\u00eautica ocorre entre 2 a 6 semanas.<\/li>\n\n\n\n<li>Podem agravar sintomas ansiosos no in\u00edcio do tratamento.<\/li>\n\n\n\n<li>A interrup\u00e7\u00e3o s\u00fabita, especialmente de f\u00e1rmacos de meia-vida curta (ex: Paroxetina), pode induzir a S\u00edndrome de Descontinua\u00e7\u00e3o.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Perfil dos F\u00e1rmacos:<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>Fluoxetina:<\/strong> Possui a meia-vida mais longa entre os ISRS. \u00c9 mais ativadora e estimulante, podendo causar ins\u00f4nia e diminui\u00e7\u00e3o do apetite. Deve ser evitada em idosos.<\/li>\n\n\n\n<li><strong>Sertralina:<\/strong> Considerada um dos ISRS preferenciais para uso na gesta\u00e7\u00e3o e lacta\u00e7\u00e3o, sendo tamb\u00e9m segura em idosos.<\/li>\n\n\n\n<li><strong>Citalopram:<\/strong> \u00c9 o ISRS com maior efeito cardiol\u00f3gico, associado ao prolongamento do intervalo QTc.<\/li>\n\n\n\n<li><strong>Escitalopram:<\/strong> \u00c9 o f\u00e1rmaco da classe mais bem tolerado, com menores taxas de intera\u00e7\u00f5es medicamentosas via CYP450. \u00c9 prefer\u00edvel para uso em idosos.<\/li>\n\n\n\n<li><strong>Paroxetina:<\/strong> Apresenta a\u00e7\u00e3o anticolin\u00e9rgica muscar\u00ednica, conferindo efeito sedativo. \u00c9 o ISRS mais associado a ganho ponderal e s\u00edndrome de descontinua\u00e7\u00e3o. Seu uso est\u00e1 associado a defeitos cong\u00eanitos card\u00edacos no 1\u00ba trimestre de gesta\u00e7\u00e3o e deve ser evitado em idosos.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Efeitos Adversos da Classe:<\/strong> Disfun\u00e7\u00e3o sexual (diminui\u00e7\u00e3o da libido, anorgasmia) e hiponatremia (secund\u00e1ria \u00e0 SIADH).<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_IRSN_Inibidores_de_Recaptacao_de_Serotonina_e_Noradrenalina_%E2%80%93_Duais\"><\/span><strong>2. IRSN (Inibidores de Recapta\u00e7\u00e3o de Serotonina e Noradrenalina &#8211; Duais)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Mecanismo de A\u00e7\u00e3o:<\/strong> Inibem a recapta\u00e7\u00e3o de serotonina (SERT) e noradrenalina (NAT).<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"947\" height=\"493\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-47.png\" alt=\"\" class=\"wp-image-39745\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-47.png 947w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-47-300x156.png 300w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-47-768x400.png 768w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-47-807x420.png 807w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-47-150x78.png 150w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-47-696x362.png 696w\" sizes=\"auto, (max-width: 947px) 100vw, 947px\" \/><figcaption class=\"wp-element-caption\">\u00a0Inibidores de recapta\u00e7\u00e3o de Serotonina e Noradrenalina ou Duais. Fonte: Acervo de aulas do Grupo MedCof.<\/figcaption><\/figure>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>F\u00e1rmacos:<\/strong> Venlafaxina, Desvenlafaxina e Duloxetina.<\/li>\n\n\n\n<li><strong>Caracter\u00edsticas Gerais:<\/strong>\n<ul class=\"wp-block-list\">\n<li>A <strong>Duloxetina<\/strong> demonstra efic\u00e1cia no al\u00edvio de quadros \u00e1lgicos e nos sintomas cognitivos da depress\u00e3o.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Efeito Adverso Chave:<\/strong> Devido ao aumento dos n\u00edveis de noradrenalina, esta classe pode causar aumento da press\u00e3o arterial.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-3-irnd-inibidores-de-recaptacao-de-noradrenalina-e-dopamina\"><span class=\"ez-toc-section\" id=\"3_IRND_Inibidores_de_Recaptacao_de_Noradrenalina_e_Dopamina\"><\/span><strong>3. IRND (Inibidores de Recapta\u00e7\u00e3o de Noradrenalina e Dopamina)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Mecanismo de A\u00e7\u00e3o:<\/strong> Inibem a recapta\u00e7\u00e3o de noradrenalina (NAT) e dopamina (DAT).<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"908\" height=\"485\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-48.png\" alt=\"\" class=\"wp-image-39746\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-48.png 908w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-48-300x160.png 300w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-48-768x410.png 768w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-48-786x420.png 786w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-48-150x80.png 150w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-48-696x372.png 696w\" sizes=\"auto, (max-width: 908px) 100vw, 908px\" \/><figcaption class=\"wp-element-caption\">Inibidores de Recapta\u00e7\u00e3o de Noradrenalina e Dopamina. Fonte: Acervo de aulas do Grupo MedCof.\u00a0<\/figcaption><\/figure>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>F\u00e1rmaco:<\/strong> Bupropiona.<\/li>\n\n\n\n<li><strong>Caracter\u00edsticas Gerais:<\/strong>\n<ul class=\"wp-block-list\">\n<li>Possui a\u00e7\u00e3o ativadora e estimulante, sendo ideal para casos com &#8220;s\u00edndrome de defici\u00eancia de dopamina&#8221; ou &#8220;redu\u00e7\u00e3o do afeto positivo&#8221;.<\/li>\n\n\n\n<li>Utilizada na cessa\u00e7\u00e3o do tabagismo.<\/li>\n\n\n\n<li><strong>Vantagem:<\/strong> N\u00e3o causa disfun\u00e7\u00e3o sexual, pois n\u00e3o possui componente SERT.<\/li>\n\n\n\n<li><strong>Contraindica\u00e7\u00f5es:<\/strong> Reduz o limiar convulsivo (contraindicada em pacientes com hist\u00f3rico de convuls\u00e3o\/epilepsia). Tamb\u00e9m \u00e9 contraindicada em hist\u00f3rico de bulimia ou anorexia.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-4-antidepressivos-atipicos-e-novos\"><span class=\"ez-toc-section\" id=\"4_Antidepressivos_Atipicos_e_Novos\"><\/span><strong>4. Antidepressivos At\u00edpicos e Novos<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Mirtazapina (NaSSA):<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>Mecanismo de A\u00e7\u00e3o:<\/strong> Complexo, inclui antagonismo \u237a2-adren\u00e9rgico (aumenta NA e 5HT), antagonismo H1 (seda\u00e7\u00e3o e ganho de peso), e antagonismo 5HT2A\/5HT2C (aumenta DA e NA no c\u00f3rtex pr\u00e9-frontal).<\/li>\n\n\n\n<li><strong>Efeitos:<\/strong> Causa seda\u00e7\u00e3o (\u00fatil para ins\u00f4nia) e ganho de peso (pelo aumento do apetite). N\u00e3o cursa com disfun\u00e7\u00e3o sexual.<\/li>\n\n\n\n<li>A associa\u00e7\u00e3o de Mirtazapina + IRSN \u00e9 denominada &#8220;California rocket fuel&#8221;.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Trazodona (AIRS):<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>Mecanismo de A\u00e7\u00e3o:<\/strong> Antagonista\/inibidor da recapta\u00e7\u00e3o de serotonina. Age por antagonismo 5HT2C e 5HT2A, inibi\u00e7\u00e3o do SERT e antagonismo H1.<\/li>\n\n\n\n<li><strong>Efeitos:<\/strong> Em doses baixas, possui a\u00e7\u00e3o hipn\u00f3tica (devido ao antagonismo H1). A a\u00e7\u00e3o antidepressiva ocorre em doses mais altas. N\u00e3o causa disfun\u00e7\u00e3o sexual.<\/li>\n\n\n\n<li><strong>Efeito Adverso Poss\u00edvel:<\/strong> Priapismo.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Agomelatina:<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>Mecanismo de A\u00e7\u00e3o:<\/strong> Agonista dos receptores MT1 e MT2, e antagonista 5HT2c. Libera NA e DA no c\u00f3rtex frontal.<\/li>\n\n\n\n<li><strong>Efeito:<\/strong> Ressincroniza os ritmos circadianos.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Vortioxetina:<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>Mecanismo de A\u00e7\u00e3o:<\/strong> Apresenta a\u00e7\u00f5es farmacodin\u00e2micas diversas.<\/li>\n\n\n\n<li><strong>Efeito:<\/strong> Possui a\u00e7\u00e3o antidepressiva e pr\u00f3-cognitiva, sendo \u00fatil em depress\u00e3o com sintomas cognitivos ou associada a s\u00edndromes demenciais.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-5-adt-antidepressivos-triciclicos\"><span class=\"ez-toc-section\" id=\"5_ADT_Antidepressivos_Triciclicos\"><\/span><strong>5. ADT (Antidepressivos Tric\u00edclicos)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Mecanismo de A\u00e7\u00e3o:<\/strong> Aumentam os n\u00edveis de noradrenalina e 5HT.<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"863\" height=\"426\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-49.png\" alt=\"\" class=\"wp-image-39747\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-49.png 863w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-49-300x148.png 300w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-49-768x379.png 768w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-49-851x420.png 851w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-49-150x74.png 150w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-49-696x344.png 696w\" sizes=\"auto, (max-width: 863px) 100vw, 863px\" \/><figcaption class=\"wp-element-caption\">Antidepressivos tric\u00edclicos. Fonte: Acervo de aulas do Grupo MedCof.\u00a0<\/figcaption><\/figure>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>F\u00e1rmacos:<\/strong> Amitriptilina, Nortriptilina, Imipramina e Clomipramina.<\/li>\n\n\n\n<li><strong>Caracter\u00edsticas Gerais:<\/strong>\n<ul class=\"wp-block-list\">\n<li>S\u00e3o tratamentos de segunda linha, utilizados para depress\u00e3o resistente.<\/li>\n\n\n\n<li>Amplamente utilizados para dor cr\u00f4nica e profilaxia da cefaleia.<\/li>\n\n\n\n<li><strong>Efeitos Adversos (M\u00faltiplos):<\/strong> O principal problema desta classe \u00e9 o antagonismo de m\u00faltiplos receptores:\n<ul class=\"wp-block-list\">\n<li>Antagonismo M1 (Anticolin\u00e9rgico): Vis\u00e3o turva, sonol\u00eancia, boca seca, constipa\u00e7\u00e3o.<\/li>\n\n\n\n<li>Antagonismo H1 (Anti-histam\u00ednico): Ganho de peso, sonol\u00eancia.<\/li>\n\n\n\n<li>Antagonismo \u237a1 (Anti-adren\u00e9rgico): Queda de press\u00e3o, sonol\u00eancia, tontura.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Intoxica\u00e7\u00e3o (Superdosagem):<\/strong>\n<ul class=\"wp-block-list\">\n<li>A superdosagem \u00e9 uma emerg\u00eancia m\u00e9dica grave. O bloqueio dos canais de s\u00f3dio no SNC pode levar a coma e crises convulsivas. No cora\u00e7\u00e3o, pode causar arritmias e morte.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-6-imao-inibidores-da-monoaminoxidase\"><span class=\"ez-toc-section\" id=\"6_IMAO_Inibidores_da_Monoaminoxidase\"><\/span><strong>6. IMAO (Inibidores da Monoaminoxidase)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Mecanismo de A\u00e7\u00e3o:<\/strong> Inibem a enzima MAO (Monoaminoxidase).<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"625\" height=\"430\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-50.png\" alt=\"\" class=\"wp-image-39748\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-50.png 625w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-50-300x206.png 300w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-50-610x420.png 610w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-50-150x103.png 150w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-50-218x150.png 218w\" sizes=\"auto, (max-width: 625px) 100vw, 625px\" \/><figcaption class=\"wp-element-caption\">Inibidores da MAO (Monoaminoxidase). Fonte: Acervo de aulas do Grupo MedCof.\u00a0<\/figcaption><\/figure>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>F\u00e1rmaco:<\/strong> Tranilcipromina (inibidor da MAO-A).<\/li>\n\n\n\n<li><strong>Caracter\u00edsticas Gerais:<\/strong>\n<ul class=\"wp-block-list\">\n<li>Monoterapia de segunda linha para depress\u00e3o resistente. S\u00e3o altamente efetivos para Transtorno de P\u00e2nico (TP) e Transtorno de Ansiedade Social (TAS).<\/li>\n\n\n\n<li><strong>&#8220;Cheese Effect&#8221; (Efeito Queijo):<\/strong> Intera\u00e7\u00e3o cl\u00e1ssica. A tiramina (presente em queijos e outros alimentos) associada \u00e0 inibi\u00e7\u00e3o da MAO-A impede a degrada\u00e7\u00e3o da tiramina, levando a uma maior libera\u00e7\u00e3o de noradrenalina. Isso resulta em um aumento da press\u00e3o arterial, podendo causar uma crise hipertensiva.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"584\" height=\"427\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-51.png\" alt=\"\" class=\"wp-image-39749\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-51.png 584w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-51-300x219.png 300w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-51-574x420.png 574w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/11\/image-51-150x110.png 150w\" sizes=\"auto, (max-width: 584px) 100vw, 584px\" \/><figcaption class=\"wp-element-caption\">Representa\u00e7\u00e3o do Cheese Effect. Fonte: Acervo de aulas do Grupo MedCof.\u00a0<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-complicacoes-e-topicos-especiais\"><span class=\"ez-toc-section\" id=\"Complicacoes_e_Topicos_Especiais\"><\/span><strong>Complica\u00e7\u00f5es e T\u00f3picos Especiais<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-depressao-resistente-ao-tratamento\"><span class=\"ez-toc-section\" id=\"Depressao_Resistente_ao_Tratamento\"><\/span><strong>Depress\u00e3o Resistente ao Tratamento<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>F\u00e1rmacos Potencializadores:<\/strong> Quando h\u00e1 falha terap\u00eautica, podem ser usados adjuvantes, como antipsic\u00f3ticos (Aripiprazol, Brexpiprazol, Quetiapina), L\u00edtio ou Horm\u00f4nios tireoidianos.<\/li>\n\n\n\n<li><strong>Cetamina\/Escetamina:<\/strong> A Cetamina, um antagonista do receptor NMDA, tem potencial na depress\u00e3o resistente. A Escetamina (formula\u00e7\u00e3o intranasal) \u00e9 usada como antidepressivo agudo.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-sindrome-serotoninergica\"><span class=\"ez-toc-section\" id=\"Sindrome_Serotoninergica\"><\/span><strong>S\u00edndrome Serotonin\u00e9rgica<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Causa:<\/strong> Excesso de atividade serotonin\u00e9rgica no SNC e perif\u00e9rico. Geralmente resulta da associa\u00e7\u00e3o de IMAO com antidepressivos que inibem a recapta\u00e7\u00e3o de serotonina, mas tamb\u00e9m pode ocorrer entre ISRS e Trazodona.<\/li>\n\n\n\n<li><strong>Tr\u00edade Cl\u00ednica:<\/strong> Apresenta dist\u00farbios cognitivo-comportamentais, auton\u00f4micos e neuromusculares.<\/li>\n\n\n\n<li><strong>Diagn\u00f3stico (Hunter Criteria):<\/strong> Baseia-se na hist\u00f3ria de uso de f\u00e1rmaco seroton\u00e9rgico associado a achados espec\u00edficos, como:\n<ul class=\"wp-block-list\">\n<li>Cl\u00f4nus espont\u00e2neo.<\/li>\n\n\n\n<li>Cl\u00f4nus induzido + agita\u00e7\u00e3o ou diaforese.<\/li>\n\n\n\n<li>Cl\u00f4nus ocular + agita\u00e7\u00e3o ou diaforese.<\/li>\n\n\n\n<li>Tremor + hiperreflexia.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Achado Diferencial:<\/strong> A presen\u00e7a de <strong>mioclonia<\/strong> fala mais a favor de S\u00edndrome Serotonin\u00e9rgica do que de S\u00edndrome Neurol\u00e9ptica Maligna.<\/li>\n\n\n\n<li><strong>Manejo:<\/strong> Requer cuidados em servi\u00e7o de emerg\u00eancia. Inclui a descontinua\u00e7\u00e3o do medicamento, uso de sedativos (Benzodiazep\u00ednicos) e o ant\u00eddoto antisseroton\u00e9rgico <strong>Ciproeptadina<\/strong>.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-garanta-sua-vaga-na-residencia-medica-com-as-melhores-condicoes-do-ano\"><span class=\"ez-toc-section\" id=\"Garanta_sua_vaga_na_residencia_medica_com_as_melhores_condicoes_do_ano\"><\/span><strong>Garanta sua vaga na resid\u00eancia m\u00e9dica com as melhores condi\u00e7\u00f5es do ano!<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Se voc\u00ea quer conquistar a\u00a0<strong>vaga de resid\u00eancia medica dos sonhos<\/strong>, o\u00a0<strong>Extensivo 2.0 MedCof<\/strong>\u00a0\u00e9 o caminho mais assertivo:\u00a0<strong>m\u00e9todo direto ao ponto, rota de estudos para quem tem pouco tempo<\/strong>\u00a0e o\u00a0<strong>melhor hist\u00f3rico de aprova\u00e7\u00e3o do pa\u00eds.<\/strong>\u00a0Garanta sua vaga agora com as melhores condi\u00e7\u00f5es do ano na\u00a0<strong>Black November!<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/extensivo.grupomedcof.com.br\/\" target=\"_blank\" rel=\" noreferrer noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"214\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/09\/Banner-Blog-TEEM-1024x214.png\" alt=\"\" class=\"wp-image-39653\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/09\/Banner-Blog-TEEM-1024x214.png 1024w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/09\/Banner-Blog-TEEM-300x63.png 300w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/09\/Banner-Blog-TEEM-768x161.png 768w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/09\/Banner-Blog-TEEM-1536x321.png 1536w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/09\/Banner-Blog-TEEM-2048x428.png 2048w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/09\/Banner-Blog-TEEM-2009x420.png 2009w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/09\/Banner-Blog-TEEM-150x31.png 150w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/09\/Banner-Blog-TEEM-696x146.png 696w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/09\/Banner-Blog-TEEM-1068x223.png 1068w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2025\/09\/Banner-Blog-TEEM-1920x401.png 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"youtube-embed\" data-video_id=\"ONMqEILTb_g\"><iframe loading=\"lazy\" title=\"Transtorno de humor - parte II. Com Dr. Tio Carl\u00e3o\" width=\"696\" height=\"392\" src=\"https:\/\/www.youtube.com\/embed\/ONMqEILTb_g?feature=oembed&#038;enablejsapi=1\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Conheca a Hip\u00f3tese Monoamin\u00e9rgica, uma teoria sobre a depress\u00e3o que sugere que ela resulta de uma defici\u00eancia de neurotransmissores.<\/p>\n","protected":false},"author":21,"featured_media":39750,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[216],"tags":[3340,3341,232],"ppma_author":[3617],"class_list":{"0":"post-39740","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-psiquiatria","8":"tag-antidepressivos","9":"tag-deficiencia-de-neurotransmissores","10":"tag-depressao"},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.3 (Yoast SEO v27.4) - 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