{"id":50412,"date":"2026-10-16T11:48:02","date_gmt":"2026-10-16T14:48:02","guid":{"rendered":"https:\/\/www.grupomedcof.com.br\/blog\/?p=50412"},"modified":"2026-10-16T11:50:26","modified_gmt":"2026-10-16T14:50:26","slug":"ministerio-da-saude-protocola-tratamento-de-hemofilia-a-para-criancas-sem-inibidores-do-fator-anti-hemofilico","status":"publish","type":"post","link":"https:\/\/www.grupomedcof.com.br\/blog\/ministerio-da-saude-protocola-tratamento-de-hemofilia-a-para-criancas-sem-inibidores-do-fator-anti-hemofilico\/","title":{"rendered":"Minist\u00e9rio da Sa\u00fade protocola tratamento de hemofilia A para crian\u00e7as sem inibidores do fator anti-hemof\u00edlico"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/nappy-uZfEs-OW9OQ-unsplash-1024x683.jpg\" alt=\"\" class=\"wp-image-50486\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/nappy-uZfEs-OW9OQ-unsplash-1024x683.jpg 1024w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/nappy-uZfEs-OW9OQ-unsplash-768x512.jpg 768w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/nappy-uZfEs-OW9OQ-unsplash-300x200-1.jpg 300w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/nappy-uZfEs-OW9OQ-unsplash-1536x1024.jpg 1536w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/nappy-uZfEs-OW9OQ-unsplash-2048x1365.jpg 2048w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/nappy-uZfEs-OW9OQ-unsplash-150x100-1.jpg 150w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/nappy-uZfEs-OW9OQ-unsplash-324x216.jpg 324w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/nappy-uZfEs-OW9OQ-unsplash-696x464.jpg 696w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/nappy-uZfEs-OW9OQ-unsplash-1068x712.jpg 1068w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/nappy-uZfEs-OW9OQ-unsplash-1920x1280.jpg 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Imagem: Unsplash<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">O <strong>Minist\u00e9rio da Sa\u00fade<\/strong>, por meio da Secretaria de Aten\u00e7\u00e3o Especializada \u00e0 Sa\u00fade e Secretaria de Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o em Sa\u00fade, <strong>aprovou<\/strong> o protocolo de uso de <strong>Emicizumabe<\/strong> para o tratamento de <strong>crian\u00e7as de 0 a 6 anos com hemofilia A sem inibidores<\/strong> do fator VIII (ou fator anti-hemof\u00edlico) da coagula\u00e7\u00e3o sangu\u00ednea.<\/p>\n\n\n\n<h2 id=\"h-hemofilia-a\" class=\"wp-block-heading\"><strong>Hemofilia A<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A <strong>hemofilia A<\/strong> \u00e9 uma <strong>doen\u00e7a gen\u00e9tica e heredit\u00e1ria<\/strong> que consiste na <strong>aus\u00eancia ou defeito do fator VIII<\/strong>, uma das prote\u00ednas da coagula\u00e7\u00e3o. Ela ocorre devido a uma muta\u00e7\u00e3o gen\u00e9tica no gene F8 presente no cromossomo X.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dentre os sintomas est\u00e3o: <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Hematomas;<\/li>\n\n\n\n<li>Dor ou incha\u00e7o nas articula\u00e7\u00f5es;<\/li>\n\n\n\n<li>Sangue na urina ou nas fezes;<\/li>\n\n\n\n<li>Sangramentos gastrointestinais;<\/li>\n\n\n\n<li>Dor de cabe\u00e7a;<\/li>\n\n\n\n<li>V\u00f4mitos repetidos;<\/li>\n\n\n\n<li>Sonol\u00eancia, e <\/li>\n\n\n\n<li>Fraqueza.<\/li>\n<\/ul>\n\n\n\n<h3 id=\"h-fatores-de-coagulacao\" class=\"wp-block-heading\"><strong>Fatores de coagula\u00e7\u00e3o<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Quando h\u00e1 um sangramento no corpo, a <strong><a href=\"https:\/\/www.grupomedcof.com.br\/blog\/coagulacao-sanguinea-explore-o-mecanismo-fisiologico\/\" target=\"_blank\" rel=\"noreferrer noopener\">cascata de coagula\u00e7\u00e3o<\/a><\/strong> \u00e9 ativada. Muitas vezes um agrupamento de plaquetas j\u00e1 resolve um pequeno sangramento, por\u00e9m, nos maiores \u00e9 preciso da ajuda de outras estruturas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Os <strong>fatores de coagula\u00e7\u00e3o sangu\u00ednea<\/strong> s\u00e3o prote\u00ednas que, ap\u00f3s uma cadeia de rea\u00e7\u00f5es qu\u00edmicas, formam o co\u00e1gulo sangu\u00edneo. Ao todo s\u00e3o <strong>13 fatores<\/strong> nomeados de I a XIII, sendo que altera\u00e7\u00f5es no fator VIII causam a hemofilia A por conta do seu papel na amplifica\u00e7\u00e3o da coagula\u00e7\u00e3o junto ao fator IX (em que a aus\u00eancia ou defici\u00eancia causa a hemofilia B).<\/p>\n\n\n\n<h2 id=\"h-uso-do-emicizumabe\" class=\"wp-block-heading\"><strong>Uso do Emicizumabe<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">O <strong>emicizumabe<\/strong> \u00e9 um medicamento composto, principalmente, por um <strong>anticorpo<\/strong> utilizado na <strong>preven\u00e7\u00e3o de sangramentos<\/strong> em pacientes com hemofilia A. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Esse anticorpo <strong>imita a fun\u00e7\u00e3o do fator VIII<\/strong>. A aplica\u00e7\u00e3o \u00e9 subcut\u00e2nea e, por isso, \u00e9 um <strong>tratamento menos invasivo<\/strong> do que a terapia tradicional com a infus\u00e3o venosa do fator VIII proveniente de transfus\u00e3o sangu\u00ednea.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/mcf.onl\/r\/blog-banner-emicizumabe-black-november-anest\" target=\"_blank\" rel=\" noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"320\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/07\/RESIDENCIA-MEDICA-1-1024x320.png\" alt=\"MedCof Anest Black November\" class=\"wp-image-50436\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/07\/RESIDENCIA-MEDICA-1-1024x320.png 1024w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/07\/RESIDENCIA-MEDICA-1-300x94.png 300w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/07\/RESIDENCIA-MEDICA-1-768x240.png 768w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/07\/RESIDENCIA-MEDICA-1-1536x480.png 1536w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/07\/RESIDENCIA-MEDICA-1-1344x420.png 1344w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/07\/RESIDENCIA-MEDICA-1-150x47.png 150w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/07\/RESIDENCIA-MEDICA-1-696x218.png 696w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/07\/RESIDENCIA-MEDICA-1-1068x334.png 1068w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/07\/RESIDENCIA-MEDICA-1.png 1600w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<h2 id=\"h-o-que-mudou\" class=\"wp-block-heading\"><strong>O que mudou?<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A aprova\u00e7\u00e3o do protocolo de uso do emicizumabe para o tratamento da hemofilia A em crian\u00e7as de 0 a 6 anos sem a presen\u00e7a de inibidores do fator VIII permite que esse p\u00fablico tenha acesso a um m\u00e9todo preventivo <strong>menos invasivo e repetitivo<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Por\u00e9m, o emicizumabe \u00e9 utilizado <strong>apenas<\/strong> na preven\u00e7\u00e3o de sangramentos. Em casos de hemorragias, o paciente receber\u00e1 a infus\u00e3o de fator VIII endovenosa para auxiliar no processo de coagula\u00e7\u00e3o sangu\u00ednea.<\/p>\n\n\n\n<h3 id=\"h-inibidores-do-fator-viii\" class=\"wp-block-heading\"><strong>Inibidores do Fator VIII<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Os <strong>inibidores do fator VIII<\/strong> s\u00e3o um dos principais obst\u00e1culos no tratamento da hemofilia A. Eles s\u00e3o <strong>aloanticorpos<\/strong> direcionados contra o fator de coagula\u00e7\u00e3o infundido durante o tratamento de reposi\u00e7\u00e3o.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Uma vez presentes, os inibidores <strong>interferem na resposta aos sangramentos<\/strong>, levando \u00e0 inefici\u00eancia do fator VIII de coagula\u00e7\u00e3o. Nestes casos, o \u00fanico tratamento capaz de erradicar a maior parte dos inibidores \u00e9 a imunotoler\u00e2ncia, que requer a infus\u00e3o peri\u00f3dica de altas doses do fator VIII de coagula\u00e7\u00e3o por longo tempo. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Al\u00e9m disso, deve-se considerar que os inibidores podem recidivar ap\u00f3s o tratamento de imunotoler\u00e2ncia. O emicizumabe consegue escapar desses inibidores e, assim, restaurar parte da capacidade de coagula\u00e7\u00e3o.<\/p>\n\n\n\n<h3 id=\"h-atualizacao-do-protocolo-na-integra\" class=\"wp-block-heading\"><strong>Atualiza\u00e7\u00e3o do protocolo na \u00edntegra<\/strong><\/h3>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/Protocolo-Emicizumabe-Atualizacao-2026.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Incorporado de Protocolo-Emicizumabe-Atualiza\u00e7\u00e3o-2026.\"><\/object><a id=\"wp-block-file--media-29240c0a-ca6a-4beb-84bd-be4a147ca706\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/Protocolo-Emicizumabe-Atualizacao-2026.pdf\">Protocolo-Emicizumabe-Atualiza\u00e7\u00e3o-2026<\/a><a href=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/Protocolo-Emicizumabe-Atualizacao-2026.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-29240c0a-ca6a-4beb-84bd-be4a147ca706\">Baixar<\/a><\/div>\n\n\n\n<h2 id=\"h-protocolo-de-2024-na-integra\" class=\"wp-block-heading\"><strong>Protocolo de 2024 na \u00edntegra<\/strong><\/h2>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/Protocolo-Emicizumabe-Integra-2024.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Incorporado de Protocolo-Emicizumabe-\u00cdntegra-2024.\"><\/object><a id=\"wp-block-file--media-6d2e3ab1-bba0-45de-9ee8-ea6c62f4678d\" href=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/Protocolo-Emicizumabe-Integra-2024.pdf\">Protocolo-Emicizumabe-\u00cdntegra-2024<\/a><a href=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/Protocolo-Emicizumabe-Integra-2024.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-6d2e3ab1-bba0-45de-9ee8-ea6c62f4678d\">Baixar<\/a><\/div>\n\n\n\n<h2 id=\"h-seja-um-medcofer\" class=\"wp-block-heading\"><strong>Seja um MedCofer!<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Quer garantir sua vaga na resid\u00eancia dos sonhos? <strong><a href=\"https:\/\/www.grupomedcof.com.br\/?utm_term=&amp;clientId=&amp;utm_campaign=enamed-continua-captacao-medcof_geral-topo&amp;utm_medium=conteudo&amp;utm_content=banner&amp;utm_source=blog\" target=\"_blank\" rel=\"noopener\">Conhe\u00e7a os preparat\u00f3rios do Grupo MedCof:<\/a><\/strong> banco de quest\u00f5es, simulados e a metodologia que j\u00e1 aprovou milhares de m\u00e9dicos em resid\u00eancia m\u00e9dica. Comece hoje a sua prepara\u00e7\u00e3o.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/mcf.onl\/r\/blog-banner-emicizumabe-home\" target=\"_blank\" rel=\" noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"320\" src=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/RESIDENCIA-MEDICA-2-3-1024x320.png\" alt=\"\" class=\"wp-image-50254\" srcset=\"https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/RESIDENCIA-MEDICA-2-3-1024x320.png 1024w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/RESIDENCIA-MEDICA-2-3-768x240.png 768w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/RESIDENCIA-MEDICA-2-3-300x94.png 300w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/RESIDENCIA-MEDICA-2-3-147x46.png 147w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/RESIDENCIA-MEDICA-2-3-298x93.png 298w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/RESIDENCIA-MEDICA-2-3-323x101.png 323w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/RESIDENCIA-MEDICA-2-3-1536x480.png 1536w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/RESIDENCIA-MEDICA-2-3-694x217.png 694w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/RESIDENCIA-MEDICA-2-3-1066x333.png 1066w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/RESIDENCIA-MEDICA-2-3-150x47.png 150w, https:\/\/www.grupomedcof.com.br\/blog\/wp-content\/uploads\/2026\/10\/RESIDENCIA-MEDICA-2-3.png 1600w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Atualiza\u00e7\u00e3o do protocolo de tratamento da hemofilia A amplia aplica\u00e7\u00e3o do medicamento preventivo Emicizumabe. <\/p>\n","protected":false},"author":75,"featured_media":50486,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[240,173],"tags":[1483,4774,4772,4773,235,869],"ppma_author":[4607],"class_list":["post-50412","post","type-post","status-publish","format-standard","has-post-thumbnail","category-noticias","category-novidades","tag-atualizacao","tag-criancas","tag-emicizumabe","tag-hemofilia-a","tag-ministerio-da-saude","tag-tratamento"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.6 (Yoast SEO v28.7) - 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